Abstract:

Diagnostic criteria for extranodal lymphoma (non-Hodgkin's lymphoma) are well known and described in the literature. However, primary extranodal lymphomas are rare and pose problems for differential diagnosis with primary or secondary lesions.

In the presented clinical case of a woman, 58 years old, with primary extranodal lymphoma of the stomach and spleen, an incorrect preoperative diagnosis was made: a tumor of the stomach and spleen abscess. It was mainly due to the presence of pain in the epigastric region and hospitalization for "severe acute biliary pancreatitis" in anamnesisd. Similar complaints and a "blurry" picture of manifestations of lymphoma did not allow her to be suspected preoperatively. The tumor nature of the focal lesion of the stomach was not in doubt, while the underestimation of MRI data, combined with the anamnesis, led to the erroneous diagnosis o f" spleen abscess". Patient underwent surgical operation: extended combined gastrectomy, distal resection of pancreas, splenectomy “en-bloc”, lymphadenectomy, cholecystectomy, “Roux-Y" reconstruction.

The clinical picture of extranodal lymphoma depends on its primary localization and the degree of its spread. Clinical manifestations of primary lymphoma of the stomach and spleen are often non­specific, therefore, against the background of previously transferred diseases of the hepatopancreatobiliary zone and their residual manifestations, an erroneous assessment of the situation is possible. In the presence of focal lesions, it is advisable to be more attentive to results of radiology examination, which can provide comprehensive information about their nature.

References

1.     WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Swerdlow S.H., Campo E., Harris N.L., Jaffe E.S., Pileri S.A., Stein H., Thiele J. (Eds). Revised 4th edition. Lyon: IARC Press, 2017; 585.

2.     Manzella A, Borba-Filho P, D'Ippolito G, Farias M. Abdominal manifestations of lymphoma: spectrum of imaging features. ISRN Radiol. 2013; 2013: 483069.

http://doi.org/10.5402/2013/483069

3.     Lee W-K, Lau EWF, Duddalwar VA, et al. Abdominal manifestations of extranodal lymphoma: spectrum of imaging findings. American Journal of Roentgenology. 2008; 191(1): 198-206.

http://doi.org/10.2214/AJR.07.3146

4.     FSBI «National Medical Research Center of Oncology named after N.N. Blokhin »of the Ministry of Health of Russia Diagnostics and treatment. Types of diseases. Lymphomas, (date of access 08.07.20) [In Russ.].

https://www.ronc.ru/grown/treatment/diseases/limfomy/

5.     Psyrri A, Papageorgiou S, Economopoulos T. Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management. Annals of Oncology. 2008; 19(12): 1992-1999.

http://doi.org/10.1093/annonc/mdn525

6.     Ghai S, Pattison J, Ghai S et al. Primary gastrointestinal lymphoma: spectrum of imaging findings with pathologic correlation. Radiographics. 2007; 27(5): 1371-1388.

http://doi.org/10.1148/rg.275065151

7.     Juarez-Salcedo LM, Sokol L, Chavez JC, Dalia S. Primary Gastric Lymphoma, Epidemiology, Clinical Diagnosis, and Treatment. Cancer Control. 2018; 25(1): 1073274818778256.

http://doi.org/10.1177/1073274818778256

8.     NORD: National Organization for Rare Disorders. Rare Disease Database. Primary Gastric Lymphoma. Luh JY Nabavizadeh N, Thomas CR. Jr., (date of access 20.07.2020).

https://rarediseases.org/rare-diseases/primary-qastric-lymphoma

9.     De Jong PA, Van Ufford HMQ, Baarslag H-J et al. CT and 18F-FDG PET for noninvasive detection of splenic involvement in patients with malignant lymphoma. American Journal of Roentgenology. 2009; 192(3): 745-753.

http://doi.org/10.2214/AJR.08.1160

10.   Ingle SB, Hinge CR. Primary splenic lymphoma: Current diagnostic trends. World J Clin Cases. 2016 December 16; 4(12): 385-389.

http://doi.org/10.12998/wjcc.v4.i12.385

11.   Dobrovolskiene L, Balukeviciute J, Maksimaitiene J. Virskinimo trakto limfomu radiologine diagnostika [Radiographic diagnosis of gastrointestinal lymphoma]. Medicina(Kaunas). 2002; 38(2):165-171.

12.   Chien SH, Liu CJ, Hu YW, et al. Frequency of surveillance computed tomography in non-Hodgkin lymphoma and the risk of secondary primary malignancies: A nationwide population-based study. Int J Cancer. 2015 Aug 1; 137(3): 658-665.

http://doi.org/10.1002/ijc.29433

13.   Chernobai TN, Golovko TS. Radiation diagnosis of extranodal lymphomas. Clinical oncology. 2017; 4(28): 73-76 (date of access 8.07.2020) [In Ukr.].

https://www.clinicaloncology.com.ua/article/19925/luchevaya-diagnostika-ekstranodalnyx-limfom

14.   Frampas E. Lymphomas: Basic points that radiologists should know. Diagnostic and Interventional Imaging. February 2013; 94(2): 131-144.

http://doi.org/10.1016/j.diii.2012.11.006

Abstract

Aim: was to study features of the clinical course, instrumental and biochemical parameters of patients with atherosclerotic aneurysmal expansion of the abdominal aorta on the base of retrospective analysis and prospective observation to determine indications for timely surgical correction.

Materials and methods: patients with the maximum diameter of the infra-renal abdominal aorta from 26 to 50mm (n=60) without primary indications for surgical treatment (endovascular abdominal aortic aneurysm repair) were selected for the prospective follow-up group. For the period of 2 years, all patients from prospective group underwent duplex scanning of the abdominal aorta every 6 months and multislice computed tomography (MSCT) of the aorta – once a year. The retrospective analysis included results of preoperative clinical-instrumental and laboratory examination of patients (n=55) who underwent endovascular aneurysm repair (EVAR) of the abdominal aorta with a maximum diameter of the infra-renal abdominal aorta more than 50mm.

Results: when comparing clinical, instrumental and biochemical parameters in patients with abdominal aortic aneurysm (AAA) before surgery and atherosclerotic aneurysmal abdominal aortic expansion of different degrees, not requiring surgical correction at the time of inclusion, it was shown that patients with AAA, statistically significantly differed from patients with AAA in clinical symptoms (pulsation and abdominal pain), burdened heredity, the number of smokers. There were no statistically significant differences in the severity of coronary and peripheral atherosclerosis. When comparing results of ultrasound duplex scanning and MSCT to estimate linear dimensions of the abdominal aorta in the group of patients with aneurysmal dilation and in the group of patients with abdominal aortic aneurysm, the comparability of results has been revealed. Prospective observation of patients with abdominal aortic aneurysmal dilation revealed predictors of disease progression: age less than 65 years, diameter of the upper third of the abdominal aorta more than 23mm, maximum diameter of the abdominal aorta more than 43mm, length of aneurismal dilation more than 52mm.

Conclusion: obtained results allowed to determine most informative indicators and criteria for the progression of atherosclerotic aneurysm expansion of the abdominal aorta, to determine further tactics of treatment, including the need for surgical correction of this pathology.

References

1.     Braithwaite B, J Cheshire N, M Greenhalgh R, Grieve R. IMPROVE Trial Investigators. Endovascular strategy or open repair for ruptured abdominal aortic aneurysm: oneyear outcomes from the IMPROVE randomized trial. Eur Heart J. 2015; 36(31): 2061-2069.

2.     Bown MJ. Meta-Analysis of 50 Years of Ruptured Abdominal Aortic Aneurysm the growth rate of small abdominal aortic aneurysms: A randomized placebocontrolled trial (AARDVARK). Eur Heart J. 2016; 37(42):3213-21.

3.     Kabardieva MR, Komlev AE, Kuchin IV, Kolmakova TE, Sharia MA, Imaev TE, Naumov VG, Akchurin RS. Abdominal aortic aneurysm: the view of a cardiologist and cardiovascular surgeon. Atherosclerosis and dyslipidemia. 2018; 33(4):17-24 [In Russ].

4.     Toghill BJ, Saratzis A, Liyanage LS, Sidloff D, Bown MJ. Genetics of Aortic Aneurysmal Disease. eLS: John Wiley & Sons, Ltd. Circulation. 2016; 133(24): 2516-2528.

5.     Kazanchian PO. Ruptures of abdominal aortic aneurysms. PO Kazanchian, VA Popov, PG Sotnikov. M.: Publisher MEI, 2006: 254 [In Russ].

6.     Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo RD, Eggebrecht H, Evangelista A, Falk V, Frank H, Gaemperli O, Grabenwoger M, Haverich A, Iung B, Manolis AJ, Meijboom F, Nienaber CA, Roffi M, Rousseau H, Sechtem U, Sirnes PA, Allmen RS, Vrints J; ESC Committee for Practice Guidelines. 2014 ESC guidelines on the diagnosis and treatment of aortic diseases: document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC). Eur Heart J. 2014: 35(41): 2873-2926.

7.     Moll FL, Powell JT, Fraedrich G, Verzini F, Haulon S, Waltham M, van Herwaarden JA, Holt PJ, van Keulen JW, Rantner B, Schlosser FJ, Setacci F, Ricco JB; European Society for Vascular Surgery. Management of abdominal aortic aneurysms clinical practice guidelines of the European Society for Vascular Surgery. Eur J Vasc Endovasc Surg. 2011; 4: 1-58.

8.     Akchurin RS, Imaev TE. Vascular diseases. Aortic aneurysms. RS Akchurin, TE Imaev. Cardiology guidelines, edited by EI Chazov; 4: 548 [In Russ].

9.     National recomendations on management of patient with abdominal aorta aneurysms. Angiology and vascular surgery. 2013; 19(2) (appendix) [In Russ].

10.   Polyakov RS, Abugov SA, Charchian ER, Pyreckiy MV, Saakyan YM. Selection of patients for endovascular prosthetics of abdominal aorta. Medical alphabet. 2016; 1 (11) (274): 33-37 [In Russ].

11.   Kuchin IV, Imaev TE, Lepilin PM, Kolegaev AS, Komlev AE, Ternovoy SK, Akchurin RS. Recent state of a problem in endovascular treatment of infrarenal abdominal aortic aneurysm. Angiology and vascular surgery. 2018; 24 (3): 60-66 [In Russ].

12.   Lindholt JS, Bjorck M, Michel JB. Anti-platelet treatment of middle-sized abdominal aortic aneurysms. Curr Vasc Pharmacol. 2013; 11(3): 305-13.

13.   Chaikof EL. The Care of Patients with an Abdominal Aortic Aneurysm: The Society for Vascular Surgery Practice Guidelines. EL Chaikof, DC Brewster, RL Dalman [et al.] J. Vasc. Surg. 2009; 50(4): Suppl. 2-49.

14.   Hirsch AT, Haskal ZJ, Hertzer NR [et al.] Practice Guidelines for the Management of Patients with Peripheral Arterial Disease. Circ. 2006; 113: 463-654.

15.   Johnston KW, Rutherford RB, Tilson MD. Suggested Standards for Reporting on Arterial Aneurysms. Subcommittee on Reporting Standards for Arterial Aneurysms, Ad Hoc Committee on Reporting Standards, Society for Vascular Surgery and North American Chapter, International Society for Cardiovascular Surgery. J. Vasc. Surg. 1991; 13 (3): 452-458.

16.   Ashton HA, Buxton MJ, Day NE, Kim LG, Marteau TM, Scott RA, et al., Multicentre Aneurysm Screening Study Group. The Multicentre Aneurysm Screening Study (MASS) into the effect of abdominal aortic aneurysm screening on mortality in men: a randomised controlled trial. Lancet. 2002;360(9345):1531-9. doi: http://dx.doi.org/10.1016/S0140-6736(02)11522-4. PubMed.

17.   Johansson M, Zahl PH, Volkert Siersma V, Jorgensen KJ, Marklund B, Brodersen J. Benefits and harms of screening men for abdominal aortic aneurysm in Sweden: a registry-based cohort study. Lancet. 2018; 391(10138): 2441-2447.

18.   Anjum A, Powell JT Is the incidence of abdominal aortic aneurysm declining in the 21st century? Mortality and hospital admissions for England & Wales and Scotland. Eur J Vasc Endovasc Surg. 2012; 43: 161-166.

Abstract:

The research is devoted to study the possibilities of functional multislice computed tomography (fMSCT) in a choice of treatment strategy, its planing and volume of surgical intervention at orbital trauma damage. MSCT and fMSCT examinations of the orbit were performed in 30 patients (60 orbits).

The obtained data allowed to develop the protocol of fMSCT, to study normal functional anatomy of the eye, to estimate normal contractile ability of extraocular muscles. The research showed the necessity of using the fMSCT of the eye of orbital trauma in assessment of contractile ability of extraocular muscles and their interest in relation to the crisis area. The improvement of diagnosis reached with the help of fMSCT, has allowed to choose an optimum tactics and volume of surgical intervention.  

References 

1.    Слободин К.Э. Лучевая диагностика по вреждений глаз. СПб. 2007.

2.    Красильников Р.Г., Варуск С.В., Жупан Б.Б. Возможности использования компьютерной и магнитнорезонансной томографии в диагностике повреждений орбит и глаза и их осложнений. Современные аспекты военной медицины. Киев. 2007; 12: 16–24.

3.    Александров Н.М., Аржанцев П.3. Травмы челюстнолицевой области. М. 1986.

4.    Слободин К.Э. Принципы, современные возможности и перспективы лучевой диагностики в офтальмологической практике. М. Вестник рентгенологии и радиологии. 2001; 1: 55–61.

5.    Бровкина А.Ф. Болезни орбиты. М. 2008.

6.    Бабий Я.С., Болгова И.М., Удовиченко В.В. Лучевые методы диагностики при заболеваниях глаза и орбиты. М. Вестник Российского научного центра рентгенологии. 2004; 3.

7.    Труфанов Г.Е., Бурлаченко Е.П. Лучевая диагностика заболеваний глаза и глазницы. СПб. 2009.

8.    Бровкина А.Ф., Яценко О.Ю., Мослехи Ш. и др. Оценка корреляции данных КТ и УЗИ при исследовании толщины экстраокулярных мышц у больных отечным экзофтальмом. М. Клиническая офтальмология. 2008; 2: 61.

9.    Бровкина А.Ф., Яценко О.Ю., Аубакирова А.С., Мослехи Ш. Компьютернотомографическая анатомия орбиты с позиции клинициста. Вестник офтальмологии. 2008; 124 (1): 11–14.

10.  Ozgen A., Ariyurec M. Normative measurements of orbital structures using CT. Am. J. Roentgenol. 1998; 170 (4): 1093–1096.

11.  Furuta M. Measurement of orbital volume by computed tomography. Еspecially on the growth of the orbit. Jpn. J. Ophthalmol. 2001; 45 (6): 600–606.

12.  Demer J.L., Miller J.M. Magnetic Resonance Imaging of the Functional anatomy of the Superiror Oblique Muscle. Investigative Ophthalmology & Visual Science. 1995; 36 (5): 209–913.

13.  Horton J.C. et al. Magnetic resonance imaging of superior oblique muscle atrophy in acquired trochlear nerve palsy [letter].

14.  Am. J. Ophthalmol. 1990; 110: 315–316.

15.  Koo E.Y. et al. MRI demonstrates normal contractility of superior rectus (SR) and inferior rectus (IR) in orbits with hypertropia. Ophthalmology. 1993; 100 (9A): 119.